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KMID : 1102020210510010006
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Applied Microscopy
2021 Volume.51 No. 1 p.6 ~ p.6
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Fractal dimension analysis as an easy computational approach to improve breast cancer histopathological diagnosis
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da Silva Lucas Glaucio
da Silva Monteiro Waleska Rayanne Sizinia
de Aguiar Moreira Tiago Medeiros
Rabelo Maria Aparecida Esteves
de Assis Emilio Augusto Campos Pereira
de Souza Gustavo Torres
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Abstract
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Histopathology is a well-established standard diagnosis employed for the majority of malignancies, including breast cancer. Nevertheless, despite training and standardization, it is considered operator-dependent and errors are still a concern. Fractal dimension analysis is a computational image processing technique that allows assessing the degree of complexity in patterns. We aimed here at providing a robust and easily attainable method for introducing computer-assisted techniques to histopathology laboratories. Slides from two databases were used: A) Breast Cancer Histopathological; and B) Grand Challenge on Breast Cancer Histology. Set A contained 2480 images from 24 patients with benign alterations, and 5429 images from 58 patients with breast cancer. Set B comprised 100 images of each type: normal tissue, benign alterations, in situ carcinoma, and invasive carcinoma. All images were analyzed with the FracLac algorithm in the ImageJ computational environment to yield the box count fractal dimension (Db) results. Images on set A on 40x magnification were statistically different (p?=?0.0003), whereas images on 400x did not present differences in their means. On set B, the mean Db values presented promissing statistical differences when comparing. Normal and/or benign images to in situ and/or invasive carcinoma (all p?
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KEYWORD
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Histopathology, Computer-aided diagnosis, Breast cancer, And fractal dimension
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